Aldose Reductase



Aldose Reductase (AldR) is an NADPH-dependent enzyme which reduces aldehydes and carbonyls. It reduces glucose to sorbitol in the glucose metabolism pathway. The AldR is implicated in diabetics and causing Iodine Deficiency Disorder (IDD) and its treatment involves the use of IDD inhibitors of AldR. The images at the left and at the right correspond to one representative AldR, i.e. the crystal structure of barley apo-Aldose Reductase (2bgq).

3D Structures of Aldose Reductase
Update June 2011

Aldose Reductase
1abn, 1ads, 3q65 - hAldR +NADP – human

1xgd – hAldR (mutant)

3q67 – hAldR (mutant)+NADP

3afm – SsAldR A1-R – Sphingomonas sp.

3afn - SsAldR A1-R+NADP

1dla – pAldR - pig

1ah4 - pAldR+NADP

3krb – AldR+NADP – Ghiardia lamblia

2bgq – bAldR - barley

2bgs - bAldR+NADP

Aldose Reductase+inhibitors
3ghr, 3ghs, 3ght, 3ghu, 2r24, 2pzn, 3g5e, 2qxw, 2iki, 2i16, 2i17, 1t40, 1t41, 1us0, 1el3 - hAldR +NADP+IDD inhibitors

3bcj, 1x97, 1x98, 1pwm, 1ef3 - hAldR+NADP+fidarestat

2pd5, 2dux, 2duz, 2dv0, 2fz8, 2fz9, 2hv5, 2hvn, 2hvo, 1mar - hAldR+NADP+zopolrestat

2fzb, 2fzd - hAldR+NADP+tolrestat

1z3n - hAldR+NADP+lidorestat

1pwl - hAldR+NADP+minalrestat

1iei - hAldR+NADP+zenarestat

1z89, 1z8a - hAldR+NADP+sulfonyl-pyridazinone

2pdg, 2pdh - hAldR+NADP+uracil inhibitor

2j8t, 1x96, 2acs, 2acu - hAldR+NADP+citrate

2acq - hAldR +NADP+glucose phosphate

2acr - hAldR +NADP+cacodylate

2ikg, 2ikh, 2ikj - hAldR+NADP+nitro-substituted inhibitor

2nvc, 2nvd - hAldR+NADP+isothiazole inhibitor

2pev, 2pf8, 2pfh - hAldR+NADP+IDD inhibitor+ fidarestat

2ipw, 2iq0, 2iqd, 2isf, 2ine, 2inz, 2is7 - hAldR+NADP+ acid

2f2k - hAldR+NADP+DEG

2pdn, 2pdq – hAldR (mutant)+NADP+uracil inhibitor

2pdb, 2pdf, 2pdi, 2pdm, 2pdx, 3len, 3m0i, 3mb9 – hAldR (mutant)+NADP+zopolrestat

2pd9, 2pdw, 2pdy, 2agt – hAldR (mutant)+NADP+fidarestat

2pdk - hAldR (mutant)+NADP+sorbinil

2pdl - hAldR (mutant)+NADP+tolrestat

1az1 – hAldR (mutant)+NADP+alrestatin

1az2 - hAldR (mutant)+NADP+citrate

3lbo, 3ld5, 3lql, 3lz5, 2pdc, 3lep, 3lqg, 3lz3, 3m4h, 2pdj, 2pdp, 2pdu, 3m64, 3mc5 - hAldR (mutant)+IDD inhibitors

3dn5 – hAldR+NADP+biaryl inhibitor

3fx4 – pAldR+NAP+thiazolidine derivative

3h4g – pAldR+NADP+fidarestat

1ah3 - pAldR+NADP+tolrestat

1ah0 - pAldR+NADP+sorbinil

1eko - pAldR+NADP+IDD inhibitor

2vdg – bAldR+NADP+butanol